Manufacturer: MSD / Merck Sharp & Dohme
Pharmaceutical name: Simvastatin
Pack: 10 pills (10 mg)
Zocor contains Simvastatin, a cholesterol-lowering drug designed to address high cholesterol by reducing elevated levels of cholesterol and triglycerides in the bloodstream, thereby lowering the risk of heart disease.
Cholesterol is essential for various bodily functions, including the formation of cell membranes, hormone production, and the transportation of fat-soluble vitamins. However, excessive cholesterol can accumulate in the artery walls, leading to blockages and an increased risk of heart disease. Simvastatin in Zocor works by lowering cholesterol production in the liver through the inhibition of HMG-CoA reductase, a key enzyme in cholesterol synthesis. Zocor decreases levels of “bad” cholesterol (LDL), which can cause the arteries to harden and become obstructed, while also boosting levels of “good” cholesterol (HDL), which assists in clearing hardened arteries. Zocor targets only the cholesterol generated in the liver and does not affect dietary cholesterol from fatty foods, underscoring the importance of maintaining a low-fat diet even when on Zocor.
The recommended dosage for Zocor (Simvastatin) ranges from 10 mg to 40 mg, taken once daily in the evening with or without meals. Treatment typically begins with a daily dose of 10 or 20 mg, but those at high risk for heart disease may be initiated on 40 mg daily. Simvastatin is only prescribed to patients who have been on a chronic dosage of simvastatin at 80 mg (for instance, for 12 months or longer) without showing signs of muscle toxicity, as this higher dose carries a greater risk of muscle-related issues, including rhabdomyolysis. Patients currently tolerating the 80 mg dose of simvastatin who require a new medication that interacts negatively with simvastatin or has a dosage restriction should be transitioned to an alternative statin or statin-based treatment that presents a lower risk for drug interactions. Those needing more than a 40 mg dose should switch to a different medication.
All medications may lead to side effects, though many individuals experience none or only minor side effects. Consult your doctor if any of the most common side effects persist or become troublesome: constipation.
Seek immediate medical attention if any severe side effects occur, such as severe allergic reactions (rash; hives; itching; difficulty breathing; chest tightness; swelling of the mouth, face, lips, or tongue); chest pain; dark urine; muscle pain, tenderness, or weakness (with or without fever and fatigue); pale stools; red, swollen, blistered, or peeling skin; severe or ongoing abdominal pain; jaundice (yellowing of the skin or eyes).